On Pestilence: A Renaissance Treatise on Plague

In the spring of 1576, the Health Office of Venice, fearful of a growing outbreak of plague, imposed a quarantine upon the city. The move was controversial, with some in power questioning the precise nature of the disease and concerned about the economic and political impact of the closure. A tribunal of physicians was summoned by the Doge, among them Girolamo Mercuriale, professor of medicine in nearby Padua and perhaps the most famous physician in all of Europe. Whatever the disease was that was affecting Venice, Mercuriale opined, it was not and could not be plague, for it was neither fast-moving nor widespread enough for that diagnosis. Following Mercuriale's advice and against the objections of the Health Office of the Republic, the quarantine was lifted. The rejoicing of the Venetian populace was short-lived. By July 1577, when the outbreak had run its course, the plague had killed an estimated 50,000 Venetians, or approximately a third of the city's population.